Focal Adhesion Cytoskeleton
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes CAVIN3, ARPC5, TLN1, TGFB1I1, PDLIM2, CNN3, TPM4, MAP1B, and MYL6 collectively encode a cytoskeletal remodeling program: caveolae scaffolding, Arp2/3-mediated actin branching, focal adhesion (talin, TGFB1I1/Hic-5), calponin/tropomyosin actin regulation, and myosin light chain. All genes are core members with uniform expression across pericyte subsets. Upregulated in IBD inflammation, consistent with pericyte cytoskeletal adaptation to inflammatory mechanical and signaling stress.
Genes
ARPC5, CAVIN3, CNN3, MAP1B, MYL6, PDLIM2, TGFB1I1, TLN1, TPM4
Most correlated modules
- Complement Regulatory Pericyte · correlation 0.92
- ER Protein Folding · correlation 0.85
- Basement Membrane Assembly · correlation 0.84
- Basement Membrane Remodeling · correlation 0.81
- Pericyte ECM Production · correlation 0.80
- ER Stress Response · correlation 0.80
- Pericyte Vascular Tone · correlation 0.78
- Inflammatory Pericyte Activation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.