Pericyte ECM Production
Gene co-expression module in Pericytes
| Category | ECM production |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes SDC2 (syndecan-2 proteoglycan), COL14A1 (fibril-associated collagen), AEBP1 (ECM/fibrosis transcription factor), and VCL (vinculin, focal adhesion) define an ECM production and cell-matrix adhesion program. CALD1 and GUCY1B1 reflect pericyte identity. TPPP3 and PMP22 are pericyte/stromal markers. The module is upregulated in IBD inflammation and reverses with treatment, consistent with pericyte-driven ECM remodeling during inflammation.
Genes
AEBP1, CALD1, COL14A1, GUCY1B1, LURAP1L, PMP22, SDC2, TPPP3, VCL
Most correlated modules
- Pericyte Identity Signaling · correlation 0.90
- Complement Regulatory Pericyte · correlation 0.88
- Pericyte Inflammatory Activation · correlation 0.84
- Smooth Muscle Contractile · correlation 0.83
- Fibrillar Collagen Production · correlation 0.82
- Pericyte Identity · correlation 0.81
- Inflammatory ECM Remodeling · correlation 0.81
- Pericyte Vascular Tone · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.