Quiescent Pericyte State
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
HOPX is a marker of quiescent stem/progenitor and pericyte states. SMOC2 (SPARC-related modular calcium-binding protein 2) is a BMP antagonist and ECM modulator expressed in intestinal stromal/pericyte populations. SLIT3 is an axon guidance and ECM-associated ligand expressed in pericytes. ITGA7 (integrin alpha7) is a smooth muscle/pericyte integrin. LPP (lipoma preferred partner) is a focal adhesion LIM protein. C1QTNF1 is a collagen-domain ECM protein. ARID5B is a transcription factor involved in adipogenesis and smooth muscle. CPE (carboxypeptidase E) is expressed in neuroendocrine and stromal cells. The combination of quiescence marker HOPX with ECM modulators and pericyte integrins suggests a quiescent pericyte state with ECM signaling capacity.
Genes
ARID5B, C1QTNF1, CPE, HOPX, ITGA7, LPP, MT2A, MTHFD2, SLIT3, SMOC2
Most correlated modules
- Hypoxia NO Signaling · correlation 0.78
- Myosin Phosphatase Regulation · correlation 0.78
- Smooth Muscle Contractile · correlation 0.75
- Pericyte ECM Production · correlation 0.70
- Inflammatory Pericyte Activation · correlation 0.63
- Inflammatory ECM Remodeling · correlation 0.61
- Pericyte Identity Differentiation · correlation 0.59
- Cytokine Inflammatory Response · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.