ECM Fibrotic Remodeling
Gene co-expression module in Endothelial
| Category | ECM remodeling |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
This module is dominated by collagen modification and ECM remodeling enzymes: LOXL2 (lysyl oxidase, crosslinks collagen/elastin), PLOD1 (lysyl hydroxylase), COLGALT1 (collagen galactosyltransferase), COL18A1 (collagen XVIII), PXDN (peroxidasin, basement membrane assembly), MMP14 (membrane-type MMP), ADAMTS7 (metalloprotease), MXRA5 (matrix remodeling). ANGPTL2 promotes inflammatory angiogenesis. CD276 (B7-H3) is expressed on tumor/inflamed endothelium. ERO1A supports ER oxidative folding of secreted proteins. The very strong inflammation signal (delta_UC=0.951) and reversal with remission indicate this is an inflammation-driven fibrotic ECM remodeling program in endothelial cells.
Genes
ADAMTS7, ANGPTL2, CD276, CETP, COL18A1, COLGALT1, DDI2, ERO1A, LBH, LOXL2, MMP14, MXRA5, MYO10, PLOD1, PXDN, TTYH3
Most correlated modules
- Inflammatory EC Activation · correlation 0.89
- Proteasomal Degradation · correlation 0.86
- UPR / ER Stress · correlation 0.83
- Vascular Barrier Integrity · correlation 0.80
- Basement Membrane Assembly · correlation 0.78
- Inflammatory EC Activation · correlation 0.77
- Inflammatory Kinase Signaling · correlation 0.74
- VEGF Tip Cell Signaling · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.