HSD17B6 — Hydroxysteroid 17-beta dehydrogenase 6
HSD17B6 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HSD17B6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Smooth Muscle Identity Cytoskeletal | ACTG2, ALDH1B1, C3orf70, CNN1, FBXL22, JPH2, KCNH2, KCNMB1 +12 more | View in SCUBA |
| Smooth muscle cells | Wnt-Hedgehog Niche Development | ADGRL3, APOC1, CLMP, CMIP, EDNRB, IRS1, LTBP3, NPNT +8 more | View in SCUBA |
About the gene
| Synonyms | HSE, RODH, SDR9C6 |
|---|---|
| Chromosome | 12: 56752161-56787790 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism, Steroid metabolism |
Function
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17- beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi- andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.