Wnt-Hedgehog Niche
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hubs are morphogen and patterning genes of the intestinal mesenchymal niche: WNT2B (Wnt niche ligand of subepithelial/muscularis mesenchyme), PTCH1 (hedgehog receptor/target in intestinal smooth muscle and fibroblasts), SEMA3D, PITX1 (hindgut/posterior positional identity), EDNRB (enteric/neural crest and mural signaling), NPNT, LTBP3 (TGF-beta bioavailability), WFDC1, ADGRL3, CLMP (visceral myopathy/intestinal development gene). This is a low-expressed but coherent developmental/positional-identity signaling program rather than an ECM structural program, distinguishing it from its collagen-rich neighbors while still being co-expressed via the shared fibroblast-like/synthetic mural state.
Genes
ADGRL3, APOC1, CLMP, CMIP, EDNRB, HSD17B6, IRS1, LTBP3, NPNT, PITX1, PPP1CC, PTCH1, PTGFRN, SEMA3D, TMEM158, WFDC1, WNT2B
Most correlated modules
- Fibroblast Matrisome · correlation 0.91
- Matrisome Regulators · correlation 0.87
- Costameric cytoskeleton · correlation 0.86
- Lysosomal-secretory processing · correlation 0.85
- Adhesion Activation · correlation 0.81
- Collagen Biosynthesis · correlation 0.76
- SMC Contractile Apparatus · correlation 0.73
- Notch-TGFbeta Signaling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.