JOSD1 — Josephin domain containing 1

JOSD1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

JOSD1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate early response BCR/AP1/NFKb pathway	CCNT1, CREM, HES4, JMY, KDM4B, NR4A3, PCNX4, PER1 +7 more	View in SCUBA
CD4⁺ T cells	TCR early activation TCR/AP1/NFKb pathway	ARIH1, BRAF, CCNT1, CLEC2D, ELL2, EMD, FAM133B, FOSL2 +11 more	View in SCUBA
Gamma-delta T cells	Late Activation Autophagy Immune regulation	BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1 +19 more
Innate lymphoid cells	Prostaglandin-AP1 Response Inflammation	ARIH1, ARL5B, CCNT1, CHD1, CXCL2, ETV3, FOSL2, IRF2BP2 +12 more	View in SCUBA
Macrophages	ER-Golgi Trafficking Vesicular traficking	ADD1, AFTPH, AZIN1, COPA, DYNC1H1, HNRNPC, LCP2, LRRFIP1 +23 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1/MEF2 Activation T cell maturation	ADNP2, BHLHE40, CDK16, DBF4, ETF1, FOSL2, GADD45A, GPR35 +8 more
Natural Killer cells	NRF2 Stress Response Stress	C1orf56, CNOT6L, CWC25, DDX18, FAM133B, KMT2E, NFE2L2, PRMT9 +2 more	View in SCUBA
Neutrophils	Inflammatory Resolution Stress	ARL5B, ATG2A, ATP2B1, BTG1, CREM, DDIT4, FOSL2, GPR65 +4 more

About the gene

Synonyms	KIAA0063
Chromosome	22: 38685543-38701556
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, Predicted intracellular proteins
Molecular function	Hydrolase, Protease
Biological process	Ubl conjugation pathway

Function

Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly- ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.