ER-Golgi Trafficking
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 32 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 15 of 32 genes have a known function matching the annotation |
Why this annotation
The top hub genes strongly implicate vesicular trafficking: COPA (COPI coat complex, Golgi-to-ER retrograde transport), SEC31A (COPII coat complex, ER-to-Golgi anterograde transport), SNX27 (sorting nexin, endosomal recycling), WASHC4 (WASH complex, endosomal actin/recycling), RAB21 (endosomal RAB GTPase), DYNC1H1 (dynein motor for vesicle transport), MTMR6 (phosphoinositide phosphatase regulating endosomes). Additional genes WIPF1 and LRRFIP1 support cytoskeletal/membrane dynamics. Several genes are enriched in mono_mac. Neighbor context with M57 (general housekeeping) is consistent with a cellular machinery module. The module represents ER-Golgi and endosomal vesicular trafficking.
Genes
ADD1, AFTPH, AZIN1, COPA, DYNC1H1, HNRNPC, JOSD1, LCP2, LRRFIP1, MED1, MTMR6, NUP58, PAFAH1B2, PPP1CB, RAB21, RHOQ, RLIM, RP2, SEC31A, SEC63, SLC25A36, SNX27, TMEM87A, TNKS2, UBE2D3, UBE3A, USO1, WAPL, WASHC4, WIPF1, WNK1, YME1L1
Most correlated modules
- Endolysosomal Trafficking · correlation 0.97
- Ubiquitin-ERAD Proteostasis · correlation 0.96
- Sphingolipid Membrane Homeostasis · correlation 0.96
- RNA Processing Transport · correlation 0.96
- RAB-mediated Trafficking · correlation 0.96
- General Cellular Maintenance · correlation 0.96
- RNA Processing Housekeeping · correlation 0.95
- Chromatin Transcriptional Regulation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.