AKR1C1 — Aldo-keto reductase family 1 member C1
AKR1C1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKR1C1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammation-activated ECM ECM remodeling | COL4A3, COL4A4, COL8A1, FAM107B, LIMA1, MAPKAP1, MEDAG, PTHLH +2 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia HIF Response Stress | AKR1C2, AKR1C3, ATP1A1, BNIP3, CARHSP1, CSRP2, CTSS, EGLN3 +4 more | View in SCUBA |
About the gene
| Synonyms | DD1, DDH, DDH1, HAKRC, MBAB |
|---|---|
| Chromosome | 10: 4963253-4983283 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha- dihydrotestosterone sulfate. Displays affinity for bile acids.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.