Inflammation-activated ECM
Gene co-expression module in Fibroblasts
| Category | ECM remodeling |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
COL8A1, COL4A3, and COL4A4 are collagens upregulated in activated/myofibroblast states. THBS2 (thrombospondin-2) promotes ECM remodeling and is a marker of activated fibroblasts. PTHLH (PTHrP) is expressed by activated stromal cells. AKR1C1 is involved in steroid/prostaglandin metabolism. Module shows the strongest upregulation in UC inflammation (delta=0.956, sig.) and is reduced in remission, indicating an inflammation-activated fibroblast ECM remodeling program.
Genes
AKR1C1, COL4A3, COL4A4, COL8A1, FAM107B, LIMA1, MAPKAP1, MEDAG, PTHLH, SH3BP5, THBS2
Most correlated modules
- Inflammatory Fibroblast Activation · correlation 0.75
- Neural-crest Fibroblast · correlation 0.73
- Submucosal Fibroblast · correlation 0.69
- CD34+ Quiescent Fibroblast · correlation 0.68
- BMP-antagonizing Fibroblast · correlation 0.65
- Wnt-niche Fibroblast · correlation 0.61
- Complement-producing Fibroblast · correlation 0.61
- PI16+ Fibroblast Identity · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.