Hypoxia HIF Response
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
BNIP3 and EGLN3 (PHD3) are canonical HIF-1α target genes induced under hypoxia. AKR1C1, AKR1C2, AKR1C3 are aldo-keto reductases known to be hypoxia-inducible. CTSS (cathepsin S) is upregulated in hypoxic conditions. FBLN5 is an ECM glycoprotein regulated by hypoxia. CARHSP1 and CSRP2 are stress-responsive. The module shows elevated delta_inflammation_CD consistent with hypoxic microenvironments in inflamed intestine. Neighbor M50 (NRF2 oxidative stress) supports a shared stress context.
Genes
AKR1C1, AKR1C2, AKR1C3, ATP1A1, BNIP3, CARHSP1, CSRP2, CTSS, EGLN3, FBLN5, MRPS6, OLFM1, PPA1
Most correlated modules
- Apoptosis Immune Regulation · correlation 0.84
- Proteasome Assembly · correlation 0.81
- Oxidative Stress Response · correlation 0.80
- NRF2 Oxidative Stress · correlation 0.79
- Genotoxic Innate Inflammation · correlation 0.75
- NF-κB Inflammatory Activation · correlation 0.73
- Actin Cytoskeletal Dynamics · correlation 0.72
- NF-κB Autophagy Regulation · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.