COL4A4 — Collagen type IV alpha 4 chain
COL4A4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL4A4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell Maturation B cell maturation | ANK3, ANTXR2, CD24, COL4A3, CSGALNACT1, ITM2C, PDCD4, PPP1R2C +3 more | View in SCUBA |
| Fibroblasts | Inflammation-activated ECM ECM remodeling | AKR1C1, COL4A3, COL8A1, FAM107B, LIMA1, MAPKAP1, MEDAG, PTHLH +2 more | View in SCUBA |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, DERL1 +29 more | View in SCUBA |
About the gene
| Synonyms | CA44 |
|---|---|
| Chromosome | 2: 227002714-227164453 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.