COL4A3 — Collagen type IV alpha 3 chain
COL4A3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL4A3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell Maturation B cell maturation | ANK3, ANTXR2, CD24, COL4A4, CSGALNACT1, ITM2C, PDCD4, PPP1R2C +3 more | View in SCUBA |
| Fibroblasts | Inflammation-activated ECM ECM remodeling | AKR1C1, COL4A4, COL8A1, FAM107B, LIMA1, MAPKAP1, MEDAG, PTHLH +2 more | View in SCUBA |
About the gene
| Chromosome | 2: 227164624-227314792 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.