Inflammatory Activation Response
Gene co-expression module in Glial cells
| Category | Inflammation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
CEBPD is a stress- and inflammation-inducible bZIP transcription factor; CD83 is an activation marker classically expressed on antigen-presenting cells but also on activated glia; IRF9 is a key interferon signaling TF (part of ISGF3); ANGPTL4 is induced by hypoxia and inflammation; GEM is a stress/signal-responsive GTPase; SAT1 is a polyamine catabolic enzyme induced by multiple stressors including p53; ODC1 is the rate-limiting polyamine synthesis enzyme; DDIT4 neighbor module context supports stress. NR2F2 is a nuclear receptor with roles in glial differentiation. IDI1 is involved in the mevalonate/isoprenoid pathway. C11orf96 and ENY2 are transcriptional regulators. The signature — CEBPD, IRF9, ANGPTL4, SAT1, GEM — is consistent with an inflammatory activation/cytokine response program. The significant increase during both UC and CD inflammation supports this. LMO4 has roles in glial development.
Genes
ANGPTL4, C11orf96, CD83, CEBPD, ENY2, GEM, IDI1, IRF9, LMO4, NR2F2, ODC1, SAT1
Most correlated modules
- Glucocorticoid Stress Recovery · correlation 0.90
- Proteostasis Stress Response · correlation 0.88
- Integrated Stress Response · correlation 0.82
- Integrated Stress Response · correlation 0.80
- DNA Damage Response · correlation 0.80
- RNA Translation Processing · correlation 0.79
- Anti-proliferative mRNA Decay · correlation 0.75
- COX-2/NF-κB Inflammation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.