LMO4 — LIM domain only 4

LMO4 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

LMO4's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	T cell co-receptors T cell development	AGO4, ARRB2, CAPG, CD200R1, CD40LG, CD96, EMB, FKBP11 +13 more	View in SCUBA
Glial cells	Inflammatory Activation Response Inflammation	ANGPTL4, C11orf96, CD83, CEBPD, ENY2, GEM, IDI1, IRF9 +3 more	View in SCUBA
Goblet cells	Chromatin Remodeling chromatin regulation & transcription	CCAR1, ENAH, FNBP1L, KDM1A, PAIP1, PBRM1, RHOBTB3, RTF1 +2 more	View in SCUBA
Hematopoietic progenitor cells	Mast Cell Differentiation Granulocyte development	ACSL4, ALOX5AP, BACE2, CDK15, CNKSR3, FAM81B, FAM83F, FOXJ1 +6 more
Innate lymphoid cells	NK Cytokine Signaling Immune regulation	BORCS7, C6orf62, DDX18, IER3, MAT2A, NSUN6, PGGHG, PLCG2 +3 more	View in SCUBA
Mucosal-associated invariant T cell	Cellular Housekeeping Housekeeping	AKR7A2, ANP32A, ANXA5, AP1M1, APEX1, APOBEC3C, CDC26, DBNL +17 more
Natural Killer cells	Cytokine Feedback Response Immune regulation	DYNLL1, N4BP2L2, PABPC1, PAXX, PRPF4B, SOCS3, TPT1, VMP1	View in SCUBA
Smooth muscle cells	Lipid Kinase Signaling Housekeeping	ABTB1, ARRDC4, CACNA1H, CBX7, CX3CL1, DGKD, DNTTIP2, FCHSD2 +10 more	View in SCUBA

About the gene

Chromosome	1: 87328880-87348923
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Biological process	Transcription, Transcription regulation

Function

Transcription cofactor. Plays a role in establishing motor neuron identity, in concert with MNX1, acting, at least in part, to disrupt LDB1-LHX3 complexes thereby negatively modulating interneuron genes in motor neurons

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.