ARHGAP21 — Rho GTPase activating protein 21
ARHGAP21 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGAP21's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Chromatin Epigenetic Regulation Housekeeping | ABHD17B, ANKH, CCNH, CTTNBP2NL, DMXL1, EEIG2, ELF2, FBXO34 +21 more | View in SCUBA |
About the gene
| Synonyms | ARHGAP10, KIAA1424 |
|---|---|
| Chromosome | 10: 24583609-24723887 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.