PLEKHO1 — Pleckstrin homology domain containing O1
PLEKHO1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLEKHO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Procoagulant TGF-β Response Inflammation | CITED4, CSF3, EHD1, F3, LAMC1, LIPG, MED24, PMEPA1 +7 more | View in SCUBA |
| Fibroblasts | Caveolae Mechanosensing Migration & adhesion | CAVIN1, FNBP1, KLHL5, LDLRAD3, MAP3K20, PDLIM3, PHLDB2, PLP2 +6 more | View in SCUBA |
| Lymphatic endothelial | Integrated Stress Response Stress | ATF4, ATP6V1B2, HNRNPH3, PPP1R18, TGIF1, UBALD2, ZFAND5 | View in SCUBA |
| Macrophages | Innate Antiviral Sensing Innate immunity | ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more | View in SCUBA |
| Natural Killer cells | NK Cytoskeletal Activation Cytoskeleton & motility | CAPG, CLNK, COTL1, EVL, GPR82, ITM2A, PEBP1, PGK1 +3 more | View in SCUBA |
| Smooth muscle cells | SMC Contractile Signaling Contractility | ACAA2, BOC, CELF2, PRUNE2, RGS2, SCARA3, SDC3 | View in SCUBA |
About the gene
| Synonyms | CKIP-1, OC120 |
|---|---|
| Chromosome | 1: 150149183-150164720 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.