Integrated Stress Response
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
ATF4 is the master transcription factor of the integrated stress response (ISR), activated downstream of eIF2α phosphorylation by HRI, PERK, GCN2, or PKR. TGIF1 is a SMAD/TGF-β repressor also regulated by ATF4. ATP6V1B2 (V-ATPase subunit) links to lysosomal stress and mTORC1 regulation. ZFAND5 (ZNF216) is involved in stress granule dynamics and ubiquitin-proteasome stress. UBALD2 contains a UBA domain relevant to ubiquitin stress sensing. PPP1R18 and HNRNPH3 are peripheral members. The module is anchored by ATF4 as a coherent ISR program.
Genes
ATF4, ATP6V1B2, HNRNPH3, PLEKHO1, PPP1R18, TGIF1, UBALD2, ZFAND5
Most correlated modules
- Stress Kinase Signaling · correlation 0.86
- NF-κB Autophagy Regulation · correlation 0.85
- NF-κB Negative Feedback · correlation 0.84
- AhR mRNA Regulation · correlation 0.84
- RNA Protein Homeostasis · correlation 0.83
- DNA Damage Autophagy · correlation 0.82
- NF-κB Inflammatory Activation · correlation 0.80
- NRF2 Oxidative Stress · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.