TGIF1 — TGFB induced factor homeobox 1
TGIF1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TGIF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Adhesion/Migration migration & adhesion | ADAM28, ADAMTS6, ARHGAP24, ARHGAP5, CHPT1, CLMN, CMTR2, FCMR +11 more | View in SCUBA |
| CD4⁺ T cells | NFAT activation TCR/AP1/NFKb pathway | AHI1, ASAP1, BCAT1, BICDL1, CPM, CYP7B1, ETV6, FAM107B +13 more | View in SCUBA |
| Fibroblasts | Hypoxia Response Stress | ACSL4, AP2S1, ARFGAP3, C4orf48, EPAS1, HIF1A, IL4R, ISG20 +8 more | View in SCUBA |
| Lymphatic endothelial | Integrated Stress Response Stress | ATF4, ATP6V1B2, HNRNPH3, PLEKHO1, PPP1R18, UBALD2, ZFAND5 | View in SCUBA |
| Macrophages | Autophagy Lysosomal Regulation Lysosomal & pahgocytosis | ADIPOR1, ARL8A, ATOSB, BCL10, BROX, CCR1, CEBPB, CHMP2B +22 more | View in SCUBA |
| Monocytes | NR4A Immediate-Early Inflammatory | ANKRD37, CHMP1B, CKS2, CYCS, EIF4A3, ETV3, GLA, NR4A1 +4 more | View in SCUBA |
About the gene
| Synonyms | HPE4, TGIF |
|---|---|
| Chromosome | 18: 3411608-3459978 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.