HNRNPH3 — Heterogeneous nuclear ribonucleoprotein H3

HNRNPH3 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HNRNPH3's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Chaperone Proteostasis Protein processing & ER	BANF1, CCT3, CCT4, CCT5, FXR1, HSPB1, MAGOH, NUDC +7 more	View in SCUBA
CD8⁺ T cells	RNA Processing Mixed RNA processing & translation	AIP, CALM1, EZR, FUBP1, HNRNPA2B1, LCP1, LRRFIP1, MOB1A +8 more	View in SCUBA
Endothelial	Rho-Actin Remodeling Cytoskeletal	ANAPC11, ARPC2, ARPC5, ATP6V0B, GNAI2, HRAS, KIF5B, PDAP1 +9 more	View in SCUBA
Gamma-delta T cells	hnRNP Splicing Complex RNA processing & translation	ASXL1, DDX21, HNRNPA1, HNRNPC, HSPA9, NOP58, PABPC1, PAPOLA +5 more
Glial cells	RNA Translation Processing RNA processing & translation	CYCS, EEF1B2, EEF1D, HNRNPA1, LDHA, NAP1L1, NPM1, PFDN5 +5 more	View in SCUBA
Innate lymphoid cells	Pyruvate Metabolism Metabolism	ABCB1, ADI1, ARID1B, ATF7IP2, CFAP298, EIF2AK2, MINDY2, MPC2 +10 more	View in SCUBA
Lymphatic endothelial	Integrated Stress Response Stress	ATF4, ATP6V1B2, PLEKHO1, PPP1R18, TGIF1, UBALD2, ZFAND5	View in SCUBA
Macrophages	Pre-mRNA Splicing Housekeeping	BCLAF1, CSNK1A1, DDX3X, DDX5, EWSR1, FUS, HNRNPH1, HNRNPU +11 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB RNA Regulation RNA processing & translation	ARIH2, ATP1A1, BCLAF1, BNIP2, CALR, COG3, DDX6, EIF4G2 +14 more

About the gene

Synonyms	2H9, HNRPH3
Chromosome	10: 68331174-68343193
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins
Molecular function	Ribonucleoprotein, RNA-binding
Biological process	mRNA processing

Function

Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.