BPNT2 — 3'(2'), 5'-bisphosphate nucleotidase 2
BPNT2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BPNT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T Cell Migration migration & adhesion | BCL2, CCDC88B, DNM2, EDC4, GMDS, LRRC58, MARK3, MDFIC +14 more | |
| Macrophages | ER-Lysosome Trafficking Vesicular traficking | CALU, CLPTM1L, CTSB, DHRS7, EMC10, GBA1, GNS, GPNMB +21 more | View in SCUBA |
About the gene
| Synonyms | FLJ20421, gPAPP, IMPA3, IMPAD1 |
|---|---|
| Chromosome | 8: 56957931-56993867 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
Function
Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.