T Cell Migration
Gene co-expression module in Gamma-delta T cells
| Category | migration & adhesion |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes MYO9B (unconventional myosin with Rho-GAP activity, critical for T cell migration), CCDC88B (hematopoietic-enriched GEF involved in immune cell migration), PREX1 (Rac GEF driving lymphocyte chemotaxis), DNM2 (dynamin GTPase supporting cytoskeletal remodeling and vesicle fission), PACS1 (TGN vesicle trafficking), PPP2R5E (PP2A subunit regulating cytoskeletal signaling), PLCL2 (PLC-related, T cell receptor-proximal), and BCL2 (survival) together indicate a T lymphocyte migration and cytoskeletal organization program. Neighbor context with M153 and M32 supports these are real biological programs, not technical artifacts.
Genes
BCL2, BPNT2, CCDC88B, DNM2, EDC4, GMDS, LRRC58, MARK3, MDFIC, MGRN1, MIER1, MYO9B, PACS1, PLCL2, PPP2R5E, PPP3CA, PREX1, RAD23B, REXO1, SART1, TASOR2, U2SURP, USP14
Most correlated modules
- Transcriptional Repressor Complex · correlation 0.88
- RNA Surveillance/NMD · correlation 0.88
- Centrosome Organization · correlation 0.85
- Spliceosome Regulation · correlation 0.85
- Transcriptional Coactivation · correlation 0.84
- Chromatin Remodeling Signaling · correlation 0.84
- T Cell Maturation · correlation 0.80
- Mitochondrial RNA Processing · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.