CTSB — Cathepsin B
CTSB belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTSB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cellular biosynthesis Housekeeping | CCDC32, HDGF, MEA1, MESD, MFSD6, MRPS11, MTHFD2, NAA60 +9 more | View in SCUBA |
| Endothelial | UPR / ER Stress Protein processing & ER | CALR, CANX, CTTN, GRN, HDLBP, HSP90B1, HSPA5, HYOU1 +10 more | View in SCUBA |
| Fibroblasts | Lysosomal Stress Response Stress | ARPC1B, ATP6V0B, FAM20C, GSTO1, IKBIP, MIF, PDLIM4, PKM +3 more | View in SCUBA |
| Macrophages | ER-Lysosome Trafficking Vesicular traficking | BPNT2, CALU, CLPTM1L, DHRS7, EMC10, GBA1, GNS, GPNMB +21 more | View in SCUBA |
| Smooth muscle cells | Mesenchymal Adhesion Program Migration & adhesion | ANTXR1, BAG2, CDH11, COL12A1, FHL3, FSTL3, HEPH, PIM1 +6 more | View in SCUBA |
About the gene
| Chromosome | 8: 11842524-11869533 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.