GNS — Glucosamine (N-acetyl)-6-sulfatase
GNS belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Lysosomal Autophagy Program Stress | ABCD4, AKR1A1, ASPH, CD63, CFI, EBP, MAP1LC3A, MDH1 +4 more | View in SCUBA |
| Macrophages | ER-Lysosome Trafficking Vesicular traficking | BPNT2, CALU, CLPTM1L, CTSB, DHRS7, EMC10, GBA1, GPNMB +21 more | View in SCUBA |
About the gene
| Chromosome | 12: 64713445-64759431 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Hydrolyzes 6-sulfate groups in N-acetyl-d-glucosaminide units of heparin sulfate and keratan sulfate
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.