C9ORF78 — Chromosome 9 open reading frame 78
C9ORF78 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
C9ORF78's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Hypoxia Stress Response Stress | ARIH2, BNIP2, CHD4, FBXO7, HIF1A, HNRNPH1, JADE1, KIF21B +16 more | |
| Mucosal-associated invariant T cell | Co-transcriptional Splicing RNA processing & translation | CCDC85C, CCNK, CDKN1B, DNTTIP2, EIF4B, ILF3, LAPTM5, MADD +16 more |
About the gene
| Synonyms | CSU2, HCA59, HSPC220 |
|---|---|
| Chromosome | 9: 129827290-129835863 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Chromosome partition, mRNA processing, mRNA splicing |
Function
Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides. May also modulate exon inclusion events. Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity. Binds U5 snRNA. Required for proper chromosome segregation. Not required for splicing of shelterin components
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.