Hypoxia Stress Response
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 25 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes FBXO7 and ARIH2 are ubiquitin E3 ligases involved in proteasomal degradation. HIF1A is a master hypoxia transcription factor. MAP2K7 activates JNK stress pathway. MOAP1 is a pro-apoptotic regulator. CHD4 and JADE1 participate in chromatin/histone acetylation. KIF21B is a kinesin. The module combines ubiquitin-proteasome system components with HIF1A-driven hypoxia response, suggesting a stress-adaptive proteostasis program. Uniform expression across subsets with moderate coherence indicates a broadly active regulatory program.
Genes
ARIH2, BNIP2, C9orf78, CHD4, FBXO7, HIF1A, HNRNPH1, JADE1, KIF21B, KRR1, MAP2K7, MOAP1, NGDN, OPA1, PCIF1, POM121, PPM1D, PTPN11, SRP72, SRRM1, STARD7, TACC1, TNRC18, ZDHHC20, ZNF622
Most correlated modules
- Transcription-RNA Coupling · correlation 0.92
- mRNA Decay Regulation · correlation 0.92
- Histone Demethylase Program · correlation 0.88
- Transcriptional Coactivation · correlation 0.88
- MAPK Kinase Signaling · correlation 0.88
- Wnt-STAT3 Signaling · correlation 0.86
- Pre-mRNA Splicing · correlation 0.86
- DNA Damage Ubiquitin · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.