HIF1A — Hypoxia inducible factor 1 subunit alpha

HIF1A belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HIF1A's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Tfh IL21 help B cell help	APBB2, CDYL2, GDF7, IL21, KIAA1671, MFHAS1, MYB, PDCD1 +6 more	View in SCUBA
Endothelial	Hypoxia Response Stress	C1orf122, CRELD2, CSTB, EFHD2, FKBP1A, LAPTM4B, NECTIN2, RAB13 +3 more	View in SCUBA
Fibroblasts	Hypoxia Response Stress	ACSL4, AP2S1, ARFGAP3, C4orf48, EPAS1, IL4R, ISG20, NECTIN2 +8 more	View in SCUBA
Gamma-delta T cells	Hypoxia Stress Response Stress	ARIH2, BNIP2, C9orf78, CHD4, FBXO7, HNRNPH1, JADE1, KIF21B +16 more
Lymphatic endothelial	NF-κB Inflammatory Activation Inflammation	BCL3, CD83, INSIG1, IPO7, IRF1, KDM6B, MAP3K8, NFKBIZ +1 more	View in SCUBA
Macrophages	Hypoxia-driven Activation Inflammatory	ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more	View in SCUBA
Monocytes	Hypoxia Response Tissue adaptation	ANPEP, ELL2, GNA15, NDRG1, RUNX1, SDC4, SLC7A5, SPAG9 +2 more	View in SCUBA
Mucosal-associated invariant T cell	Hypoxia-ER Stress Stress	ANKHD1, ARID1A, ARID4B, ATXN7, CEMIP2, CPD, CTDP1, EIF2AK3 +5 more
Pericytes	NF-κB Inflammatory Activation Inflammatory	CTSS, EFHD2, IL32, LAP3, OSMR, TAPBP, TMEM165	View in SCUBA
Smooth muscle cells	ER Chaperone/UPR Protein processing & ER	CALR, CRISPLD2, FBLIM1, HSP90B1, HSPA5, IL6ST, OSMR, PCOLCE +3 more	View in SCUBA

About the gene

Synonyms	bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8
Chromosome	14: 61695513-61748259
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	Host-virus interaction, Transcription, Transcription regulation

Function

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with NCOA1 and/or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state. In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons. Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.