CHD4 — Chromodomain helicase DNA binding protein 4
CHD4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHD4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ADRA2B, CD83, CYB5D1, DUSP2, EGR2, EGR3, EGR4, FOSL1 +9 more | View in SCUBA |
| CD8⁺ T cells | Chromatin RNA Processing RNA processing & translation | EIF4G2, FLNA, GNB1, MTDH, SFPQ, SRSF11, UBXN4, ZNF207 | View in SCUBA |
| Gamma-delta T cells | Hypoxia Stress Response Stress | ARIH2, BNIP2, C9orf78, FBXO7, HIF1A, HNRNPH1, JADE1, KIF21B +16 more | |
| Macrophages | Protein Biogenesis Housekeeping | ATP6V0D1, B3GAT3, BUD23, C11orf58, CNPY2, DAZAP1, DDX46, DNAJA2 +23 more | View in SCUBA |
| Natural Killer cells | EGR2/3 NK Activation activation | AMD1, CRTAM, CSF2, DNAJB9, EGR2, EGR3, GADD45A, MAP2K3 +4 more | View in SCUBA |
About the gene
| Synonyms | Mi-2b, Mi2-BETA |
|---|---|
| Chromosome | 12: 6570082-6614524 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Essential proteins, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, DNA-binding, Hydrolase |
| Biological process | Transcription, Transcription regulation |
Function
ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.