Co-transcriptional Splicing
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 25 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 25 genes have a known function matching the annotation |
Why this annotation
The module is dominated by RNA splicing and transcription elongation factors: SF3A1 (U2 snRNP splicing factor), SRSF6 (SR splicing factor), TFIP11 (splicing/spliceosome disassembly), SRRT (mRNA capping/Microprocessor), PAPOLA (poly-A polymerase), POLR2A (RNA pol II largest subunit), SUPT5H (DSIF, transcription elongation), CCNK (Cyclin K, CDK12 partner for elongation), ILF3 (RNA binding/transcription). EIF4B links to translation. CDKN1B (p27) may reflect cell cycle context. The coherent theme is co-transcriptional RNA processing and transcription elongation coupling.
Genes
C9orf78, CCDC85C, CCNK, CDKN1B, DNTTIP2, EIF4B, ILF3, LAPTM5, MADD, MIDEAS, MOB1A, NXF1, PAPOLA, PBXIP1, POLR2A, SAFB2, SF3A1, SF3B2, SLC25A32, SRRT, SRSF6, SUPT5H, TFIP11, UBQLN1, VPS37B
Most correlated modules
- Transcription Factor Activity · correlation 0.88
- Cytoskeletal Organization · correlation 0.85
- Housekeeping Translation · correlation 0.84
- Stress Granule Response · correlation 0.84
- Nuclear-Cytoskeletal Organization · correlation 0.84
- mRNA 3' Processing · correlation 0.83
- Nuclear Receptor Chromatin · correlation 0.80
- Autophagy & Trafficking · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.