CCDC3 — Coiled-coil domain containing 3
CCDC3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCDC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Tone Regulation Endothelial cell development | ADAMTS6, ATP1A1, ATP1B3, ATP5PF, CALD1, CAVIN3, CD81, HMOX2 +13 more | View in SCUBA |
| Smooth muscle cells | Vascular SMC Identity Contractility | ADIRF, ARPC1A, BCAM, CRIP1, EFHD1, GPRC5C, GPX3, HRC +10 more | View in SCUBA |
About the gene
| Synonyms | DKFZp761F241 |
|---|---|
| Chromosome | 10: 12896625-13099652 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
Function
Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.