Vascular Tone Regulation
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 22 genes have a known function matching the annotation |
Why this annotation
Strong inflammation upregulation (delta_UC=0.45, delta_CD=0.32) with remission reversal. ATP1B3/ATP1A1 encode Na/K-ATPase subunits critical for vascular tone. CAVIN3 is a caveolae-associated protein. RHOC is a Rho GTPase regulating actomyosin contractility and vascular permeability. CALD1 (caldesmon) regulates smooth muscle/EC actin. ILK links integrins to actin. PKIG inhibits PKA (cAMP pathway). HMOX2 is heme oxygenase-2 (cytoprotective). CCDC3 is an endothelial-enriched secreted factor. CD81 is a tetraspanin involved in EC signaling. MRPL33/MRPL17 are mitochondrial ribosomal proteins (peripheral). STX12 is a SNARE protein. RGS3 regulates G-protein signaling. This module represents endothelial vascular tone regulation and caveolae-mediated signaling, strongly activated in IBD inflammation.
Genes
ADAMTS6, ATP1A1, ATP1B3, ATP5PF, CALD1, CAVIN3, CCDC3, CD81, HMOX2, ILK, KCTD10, MRPL17, MRPL33, NAA10, PKIG, POMP, RGS3, RHOC, SHROOM4, SMAD6, STX12, TCF7L1
Most correlated modules
- Hippo-YAP Cytoskeletal · correlation 0.88
- Endocytic Membrane Remodeling · correlation 0.85
- Inflammatory Angiogenic Activation · correlation 0.84
- Endothelial NO Activation · correlation 0.83
- WAVE Complex Cytoskeleton · correlation 0.82
- Endothelial Junction Identity · correlation 0.82
- Rho-Actin Remodeling · correlation 0.82
- Inflammatory Kinase Signaling · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.