CALD1 — Caldesmon 1
CALD1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CALD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Tone Regulation Endothelial cell development | ADAMTS6, ATP1A1, ATP1B3, ATP5PF, CAVIN3, CCDC3, CD81, HMOX2 +13 more | View in SCUBA |
| Glial cells | Actin Remodeling Migration migration & adhesion | CAST, CD46, GLIPR2, GSTK1, KTN1, SPATA13, TCEAL4 | View in SCUBA |
| Lymphatic endothelial | Lymphatic Specification endothelial development | ARHGAP29, BOD1L1, CLCN3, DECR1, GCC2, MINDY2, MPHOSPH8, MTUS1 +9 more | View in SCUBA |
| Pericytes | Pericyte ECM Production ECM production | AEBP1, COL14A1, GUCY1B1, LURAP1L, PMP22, SDC2, TPPP3, VCL | View in SCUBA |
| Smooth muscle cells | SMC contractile apparatus Contractility | ACTA2, ACTB, CAV1, DSTN, MYL6, MYL9, PPP1R14A, SH3BGRL +2 more | View in SCUBA |
About the gene
| Synonyms | CDM, H-CAD, h-CD, L-CAD |
|---|---|
| Chromosome | 7: 134744252-134970729 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding, Calmodulin-binding, Muscle protein |
Function
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.