CCL19 — C-C motif chemokine ligand 19
CCL19 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCL19's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | FRC function Immune interaction | ADRA2A, ANKRD29, CCL21, CTSH, GP1BA, IL3RA, KCNK13, NPB +3 more | View in SCUBA |
| Smooth muscle cells | Stromal Chemokine Secretion Inflammation | C7, CCL2, CCL21, CH25H, CXCL12, CXCL2, LINC00924, MAOA +9 more | View in SCUBA |
About the gene
| Synonyms | CKb11, ELC, exodus-3, MIP-3b, SCYA19 |
|---|---|
| Chromosome | 9: 34689570-34691276 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis, Inflammatory response |
Function
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta- arrestin (ARRB1/2) to ACKR4
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.