KCNK13 — Potassium two pore domain channel subfamily K member 13
KCNK13 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KCNK13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | FRC function Immune interaction | ADRA2A, ANKRD29, CCL19, CCL21, CTSH, GP1BA, IL3RA, NPB +3 more | View in SCUBA |
| Macrophages | PI3K Lipid Signaling Innate immunity | AGPAT4, AREG, DHX34, DNMBP, EEPD1, HIP1, IP6K1, IRAK2 +23 more | View in SCUBA |
About the gene
| Synonyms | K2p13.1, THIK-1, THIK1 |
|---|---|
| Chromosome | 14: 90061994-90185853 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Voltage-gated ion channels |
| Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
| Biological process | Ion transport, Potassium transport, Transport |
Function
K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. Contributes most of K(+) currents at the plasma membrane of resting microglia. Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses. Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.