CCR5 — C-C motif chemokine receptor 5
CCR5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCR5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CCR5 effector migration migration & adhesion | ARHGEF12, BLM, EMC6, ERGIC2, IGF2R, KAT2B, PSMD12, RAB10 +10 more | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CASK, CD84, CDC14A, CXCR6, DGKA +22 more | |
| Monocytes | Tolerogenic Monocyte Activation Inflammatory | CD40, CD80, GGT5, IDO1, IL4I1, MANF, PLA2G7, SLAMF7 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chemokine Receptor Migration migration & adhesion | CCR1, CCR2, CD47, FAM78A, KRIT1, LUC7L3, MTG1, PHF14 +6 more |
About the gene
| Synonyms | CC-CKR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 |
|---|---|
| Chromosome | 3: 46370946-46376206 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer |
| Biological process | Host-virus interaction |
Function
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.