CFL2 — Cofilin 2
CFL2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CFL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Myofibroblast Contractile Cytoskeletal | ACTA2, CCDC107, CSRP1, FLNA, ILK, LPP, MSRB3, MYL9 +7 more | View in SCUBA |
| Smooth muscle cells | SMC Contractile Apparatus Contractility | ACTG2, CKB, CSRP1, FLNA, ILK, LMOD1, MYH11, PPP1R12B +3 more | View in SCUBA |
About the gene
| Synonyms | NEM7 |
|---|---|
| Chromosome | 14: 34709113-34714823 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.