Myofibroblast Contractile
Gene co-expression module in Fibroblasts
| Category | Cytoskeletal |
|---|---|
| Genes | 16 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 14 of 16 genes have a known function matching the annotation |
Why this annotation
Core coherence module with canonical myofibroblast/smooth muscle contractile markers: ACTA2 (alpha-smooth muscle actin), TAGLN (SM22-alpha), MYL9 (myosin light chain 9), MYLK (myosin light chain kinase), TPM1 (tropomyosin 1), PPP1R12A (myosin phosphatase targeting), CSRP1 (cysteine-rich LIM domain, smooth muscle), TGFB1I1 (TGF-beta-induced, myofibroblast marker), FLNA (filamin A), PDLIM7, ILK (integrin-linked kinase), NEXN (nexilin, actin-binding), CFL2 (cofilin 2), LPP (lipoma preferred partner, focal adhesion). Significantly upregulated in UC and CD inflammation. This is the prototypical myofibroblast contractile program in intestinal fibroblasts.
Genes
ACTA2, CCDC107, CFL2, CSRP1, FLNA, ILK, LPP, MSRB3, MYL9, MYLK, NEXN, PDLIM7, PPP1R12A, TAGLN, TGFB1I1, TPM1
Most correlated modules
- Smooth Muscle Identity · correlation 0.92
- Notch Fibroblast Activation · correlation 0.92
- Focal Adhesion ECM · correlation 0.89
- Caveolae Mechanosensing · correlation 0.88
- Stromal Niche Identity · correlation 0.85
- Rho-ROCK Contractility · correlation 0.84
- TGF-beta Fibroblast Niche · correlation 0.79
- Smooth Muscle Differentiation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.