PPP1R12B — Protein phosphatase 1 regulatory subunit 12B
PPP1R12B belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP1R12B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Smooth Muscle Identity Cytoskeletal | ACTG2, ALDH1B1, C3orf70, CNN1, FBXL22, HSD17B6, JPH2, KCNH2 +12 more | View in SCUBA |
| Glial cells | Glial Neural Scaffolding Cytoskeletal | AKAP6, ARHGAP24, COL5A3, EIF4G2, NFIX, SCAF11, SEMA6D, USP53 | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | ABCC4, ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2 +20 more | View in SCUBA |
| Pericytes | Myosin Phosphatase Regulation Cytoskeletal | CALM2, CRIP1, CRYAB, HCFC1R1, JAG1, LBH, MAP3K7CL, PHLDA2 +2 more | View in SCUBA |
| Smooth muscle cells | SMC Contractile Apparatus Contractility | ACTG2, CFL2, CKB, CSRP1, FLNA, ILK, LMOD1, MYH11 +3 more | View in SCUBA |
About the gene
| Synonyms | MGC131980, MGC87886, MYPT2, PP1bp55 |
|---|---|
| Chromosome | 1: 202348699-202592706 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.