SMC Contractile Apparatus
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
Textbook visceral smooth muscle contractile apparatus: MYH11 (SMC myosin heavy chain), ACTG2 (enteric smooth muscle actin), TPM1, SMTN (smoothelin), LMOD1, CSRP1, SYNPO2 (myopodin), CFL2, FLNA and ILK (actin crosslinking / focal adhesion-actin coupling), PPP1R12B (MYPT2, myosin phosphatase targeting subunit controlling calcium sensitization), and CKB providing local ATP buffering for contraction. High mean expression (1.66) and 68% detection across all subsets confirm this is the core identity program of colonic smooth muscle cells, not contamination. Its neighbor M67 contains upstream regulators (ARHGAP42/RhoGAP, BMPR2, SOX5) that plausibly modulate this contractile output, explaining the co-expression edge.
Genes
ACTG2, CFL2, CKB, CSRP1, FLNA, ILK, LMOD1, MYH11, PPP1R12B, SMTN, SYNPO2, TPM1
Most correlated modules
- Costameric cytoskeleton · correlation 0.75
- Wnt-Hedgehog Niche · correlation 0.73
- SMC contractile apparatus · correlation 0.73
- Contractile SMC phenotype · correlation 0.67
- Lysosomal-secretory processing · correlation 0.63
- Generic maintenance transcripts · correlation 0.63
- Post-translational regulators · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.