Endosomal Vesicle Trafficking
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
The module is anchored by three RAB GTPases (RAB8A, RAB11B, RAB11A) which are master regulators of vesicular trafficking — RAB11 specifically controls recycling endosomes, and RAB8A governs exocytic/recycling routes. SNX5 (sorting nexin-5) functions in endosomal cargo sorting, CHMP1A is an ESCRT-III component for multivesicular body biogenesis, RALBP1 is a RAL effector involved in endocytosis, and VTI1B is a SNARE protein mediating vesicle fusion. ILK links integrins to vesicle-mediated trafficking. ELOVL1 and CYB5B contribute lipid metabolism context (lipid composition of vesicle membranes). PPP4C and ICMT are regulators of Ras/RAB prenylation and signaling. Together this is a coherent vesicle trafficking/endosomal recycling program. Uniform expression indicates constitutive housekeeping activity in gd T cells.
Genes
ADRM1, CDK2AP2, CHMP1A, COA6, CYB5B, ELOVL1, GNG5, HADHB, ICMT, ILK, MIEN1, PPP4C, RAB11A, RAB11B, RAB8A, RALBP1, RNPEP, SNX5, STARD3NL, VTI1B
Most correlated modules
- Transcriptional Elongation Control · correlation 0.88
- Complex I Assembly · correlation 0.87
- Basal Cell Maintenance · correlation 0.84
- Actin Remodeling · correlation 0.83
- Cellular Homeostasis · correlation 0.83
- Proteasome Complex · correlation 0.83
- Chaperone Protein Folding · correlation 0.82
- Interferon Stimulated Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.