GNG5 — G protein subunit gamma 5

GNG5 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GNG5's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ANAPC11, AP2S1, ATP5F1A, ATP5F1C, COPE, COX8A, GAPDH, NDUFB10 +7 more	View in SCUBA
CD4⁺ T cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ANP32A, ATP5F1A, ATP5F1B, COX7A2, COX7B, GADD45GIP1, MRPL21, MRPS16 +10 more	View in SCUBA
CD8⁺ T cells	Proteasome Degradation Housekeeping	ARPP19, CLTA, HSBP1, NDUFB4, POLR2J, POLR2K, PSMB2, PSMB3 +2 more	View in SCUBA
Endothelial	Oxidative Stress Response Stress	AHR, CD151, CD59, CTTNBP2NL, DSTN, FLOT2, GNB4, HYAL2 +11 more	View in SCUBA
Fibroblasts	Mitochondrial OXPHOS Mitochondrial & OxPhos	ATP5F1E, ATP5MG, ATP5PO, COX4I1, PSMB3, SERF2, UQCR11, UQCRB +1 more	View in SCUBA
Gamma-delta T cells	Endosomal Vesicle Trafficking Housekeeping	ADRM1, CDK2AP2, CHMP1A, COA6, CYB5B, ELOVL1, HADHB, ICMT +11 more
Glial cells	Mitochondrial Housekeeping Mitochondrial & OxPhos	ATP5F1D, ATP6V1G1, COX7C, RAN, SEM1, SH3BGRL3, ST3GAL4, SUB1 +3 more	View in SCUBA
Goblet cells	Proteasome Complex Protein processing & ER	DSTN, HSBP1, NDUFA4, PCBD1, PPP1CA, PSMA3, PSMB2, PSMB5 +1 more	View in SCUBA
Innate lymphoid cells	Proteasome ER Proteostasis Protein processing & ER	ATP5MC1, ATP5PF, DBI, GTF3C6, HNRNPK, IL4I1, MANF, MED10 +19 more	View in SCUBA
Lymphatic endothelial	Protein Quality Control Protein processing & ER	BCAP29, CD99, CDC42, DYNLRB1, NDUFV2, PDCD6, PFDN5, SKP1 +1 more	View in SCUBA
Macrophages	Glycolytic Redox Metabolism Lipid metabolism	AGPAT2, ANXA5, ATP6V1F, BCKDK, BRI3, C1orf122, CLIC1, ELOC +18 more	View in SCUBA
Mucosal-associated invariant T cell	NADPH Oxidase & Innate Immune Inflammation	ATP5F1D, ATP5MC3, COX5A, CYBA, FXYD5, GABARAP, HIGD2A, HINT1 +9 more
Natural Killer cells	hnRNP RNA Processing RNA processing & translation	CBX3, HNRNPA2B1, HNRNPA3, HNRNPAB, RAN, SLC25A5, YWHAE	View in SCUBA
Smooth muscle cells	Basal metabolic housekeeping Housekeeping	AP2S1, CNN2, GSTM3, IMPDH2, KIF5B, OSTC, PRDX4, VDAC3	View in SCUBA

About the gene

Chromosome	1: 84498323-84506581
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, RAS pathway related proteins
Molecular function	Transducer

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.