COA6 — Cytochrome c oxidase assembly factor 6
COA6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COA6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Respiratory chain assembly Mitochondrial & OxPhos | COA4, CYC1, EBNA1BP2, ERCC1, POLR2E, PRELID3B, PSMD3, VMA21 | View in SCUBA |
| Gamma-delta T cells | Endosomal Vesicle Trafficking Housekeeping | ADRM1, CDK2AP2, CHMP1A, CYB5B, ELOVL1, GNG5, HADHB, ICMT +11 more | |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, CSNK2B, CYB5R3, DEGS1, DYNLRB1 +20 more | View in SCUBA |
About the gene
| Synonyms | C1orf31 |
|---|---|
| Chromosome | 1: 234373456-234385080 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.