CDK2AP2 — Cyclin dependent kinase 2 associated protein 2
CDK2AP2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDK2AP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER stress UPR Protein processing & ER | CCT2, CRELD2, DDX39A, DNAJB11, DSTN, EIF5A, GPSM3, GTF3A +9 more | View in SCUBA |
| CD8⁺ T cells | Actin Cytoskeleton Dynamics Cytoskeletal | ACTG1, ACTR3, ANXA11, ARPC2, CAP1, RAC2, RNF181 | View in SCUBA |
| Endothelial | Inflammatory Lipid Metabolism Metabolite transfer | ACSL4, APOL1, COPS8, GBE1, GOLM1, MAPRE1, NPC1, PDLIM7 +5 more | View in SCUBA |
| Gamma-delta T cells | Endosomal Vesicle Trafficking Housekeeping | ADRM1, CHMP1A, COA6, CYB5B, ELOVL1, GNG5, HADHB, ICMT +11 more | |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CEP83, COL4A4, DERL1 +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial OxPhos Mitochondrial & OxPhos | ATP5PD, CD63, COX7A2L, MDH1, MESD, MRPS18C, MRPS31, NDUFS2 +5 more | |
| Natural Killer cells | S/G2M Cell Cycle Cell cycle | CALM2, CKS2, JPT1, KPNA2, NAP1L1, NASP, PRDX1, TUBA1C | View in SCUBA |
About the gene
| Synonyms | DOC-1R, p14 |
|---|---|
| Chromosome | 11: 67506497-67508649 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A. Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (By similarity). Regulates microtubule organization of metaphase II oocytes (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.