ICMT — Isoprenylcysteine carboxyl methyltransferase
ICMT belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ICMT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | DNA Replication Cell cycle | CENPX, DNMT1, IDH2, MCM3, MCM4, MCM5, MCM6, NR2C2AP +11 more | View in SCUBA |
| Gamma-delta T cells | Endosomal Vesicle Trafficking Housekeeping | ADRM1, CDK2AP2, CHMP1A, COA6, CYB5B, ELOVL1, GNG5, HADHB +11 more | |
| Macrophages | DNA Replication Metabolism Cell cycle | AGPAT5, CBX1, DCK, FADS1, HACD3, HADH, IDH2, MTHFD1 +11 more | View in SCUBA |
About the gene
| Synonyms | HSTE14, PCCMT, PPMT |
|---|---|
| Chromosome | 1: 6221193-6235972 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins |
| Molecular function | Methyltransferase, Transferase |
Function
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.