FGD4 — FYVE, RhoGEF and PH domain containing 4
FGD4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FGD4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Tissue-resident memory B B cell maturation | CALHM2, CCR1, CMTM7, FCRL4, GSN, ITGB7, PIK3R6, PLD4 +4 more | View in SCUBA |
| Endothelial | TRAIL-mediated Apoptosis Stress | CLDN15, ELOVL7, EVA1C, ISCU, LMCD1, SELENOM, TIMMDC1, TMEM273 +2 more | View in SCUBA |
| Enterocytes | YAP cytoskeletal remodeling Migration & adhesion | ABLIM1, AHCYL2, ARHGAP26, CCSER1, CDC42BPA, ITGB8, PDE4D, PIP5K1B +5 more | View in SCUBA |
| Macrophages | Innate Immune Dampening Innate immunity | DCAF6, ELL2, FKBP5, IRAK3, MAP2K4, MOB3B, PACSIN2, PAPSS2 +10 more | View in SCUBA |
| Neutrophils | Neutrophil Survival FOXO-MK2 Developmental | ARIH1, FCAR, FOXO3, HECA, IPMK, MAP3K2, MAPKAPK2, RAB8B +1 more |
About the gene
| Synonyms | CMT4H, frabin, FRABP, ZFYVE6 |
|---|---|
| Chromosome | 12: 32399558-32646050 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding, Guanine-nucleotide releasing factor |
Function
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.