TRAIL-mediated Apoptosis
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
TNFRSF10A (TRAIL receptor 1/DR4) is a death receptor mediating extrinsic apoptosis. EVA1C is linked to autophagy and apoptotic signaling. TIMMDC1 is required for mitochondrial complex I assembly, and ISCU is essential for iron-sulfur cluster biogenesis in mitochondria — both relevant to mitochondrial integrity during stress. SELENOM is an ER-resident selenoprotein involved in redox homeostasis. LMCD1 is a transcriptional regulator induced by inflammatory stimuli. CLDN15 (claudin-15) is a tight junction protein whose dysregulation occurs in inflammation. ELOVL7 participates in fatty acid elongation relevant to membrane lipid remodeling. The module is upregulated in both UC and CD inflammation and reversed in UC remission, consistent with an inflammatory apoptotic/stress response in endothelial cells.
Genes
CLDN15, ELOVL7, EVA1C, FGD4, ISCU, LMCD1, SELENOM, TIMMDC1, TMEM273, TNFRSF10A, ZNRF1
Most correlated modules
- IL-13/STAT6 Signaling · correlation 0.80
- Immune Cell Contamination · correlation 0.71
- Oxidative Stress Response · correlation 0.70
- IL33 Alarmin Signaling · correlation 0.69
- Myeloid Contamination · correlation 0.67
- Endothelial Barrier Homeostasis · correlation 0.56
- Endothelial Quiescence · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.