ISCU — Iron-sulfur cluster assembly enzyme
ISCU belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ISCU's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cytoskeleton/motility migration & adhesion | ANXA2, ANXA4, BHLHE41, C4orf48, CAPG, CAPN2, CIB1, LGALS1 +11 more | View in SCUBA |
| CD4⁺ T cells | MAF regulatory program Immune regulation | AKAP13, ARID4B, DTHD1, FYN, IKZF3, LIMA1, LIMS1, MAF +12 more | View in SCUBA |
| Endothelial | TRAIL-mediated Apoptosis Stress | CLDN15, ELOVL7, EVA1C, FGD4, LMCD1, SELENOM, TIMMDC1, TMEM273 +2 more | View in SCUBA |
| Fibroblasts | Metabolic Homeostasis Housekeeping | ADH5, ALDH2, ATP2B1, NBL1, NLGN4X, PGM1, PKIG, RAB7A +4 more | View in SCUBA |
| Innate lymphoid cells | ILC-1 identity Differentiation | ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3 +20 more | View in SCUBA |
| Lymphatic endothelial | Metabolic Housekeeping Housekeeping | CAPNS1, CYB5R3, DMAC1, DUT, EID1, ESD, GNAI2, OCIAD1 +5 more | View in SCUBA |
| Smooth muscle cells | Ubiquitous Housekeeping Transcripts Housekeeping | ATP6V1G1, C12orf57, CIRBP, FIS1, GSTP1, NDUFB8, NUPR1, PEBP1 +3 more | View in SCUBA |
About the gene
| Synonyms | hnifU, ISU2, NIFUN |
|---|---|
| Chromosome | 12: 108562582-108569368 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
Function
Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (Probable). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.