COX14 — Cytochrome c oxidase assembly factor COX14
COX14 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COX14's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Oxidative phosphorylation Mitochondrial & OxPhos | ACADVL, CHMP1A, EIF2AK1, EML2, ETFA, GPR108, NDUFA8, PARP1 +12 more | View in SCUBA |
| Macrophages | Mitochondrial Complex Assembly Mitochondrial & OxPhos | LAMTOR1, MRPL43, NDUFA8, NDUFC1, SMIM26, SURF1, TADA3, VPS28 | View in SCUBA |
| Smooth muscle cells | Basal Maintenance Genes Housekeeping | ANAPC16, C1QTNF2, C7orf50, CCNI, COX8A, HNRNPA1, MRPL33, PPP1CB +3 more | View in SCUBA |
About the gene
| Synonyms | C12orf62, MGC14288 |
|---|---|
| Chromosome | 12: 50112082-50120457 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted membrane proteins |
Function
Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.