Mitochondrial Complex Assembly
Gene co-expression module in Macrophages
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Top hub genes LAMTOR1 (Ragulator complex, lysosomal mTORC1 anchoring) and VPS28 (ESCRT-I endosomal sorting) point to lysosomal/endosomal trafficking. COX14 and SURF1 are cytochrome c oxidase (Complex IV) assembly factors; NDUFA8 and NDUFC1 are Complex I subunits; MRPL43 is a mitoribosomal protein. TADA3 is a SAGA complex subunit. The module is small (9 genes), weakly coherent, and uniformly expressed. The mitochondrial respiratory chain assembly theme (COX14, SURF1, NDUFA8, NDUFC1, MRPL43) is the strongest signal, with LAMTOR1/VPS28 representing lysosomal co-regulation. Neighboring modules M17 and M79 also contain OXPHOS subunits, supporting a mitochondrial housekeeping neighborhood.
Genes
COX14, LAMTOR1, MRPL43, NDUFA8, NDUFC1, SMIM26, SURF1, TADA3, VPS28
Most correlated modules
- Protein Homeostasis Mixed · correlation 0.96
- Mitochondrial Biogenesis · correlation 0.95
- Oxidative Phosphorylation · correlation 0.94
- Proteasome UPS · correlation 0.94
- Mitochondrial OXPHOS · correlation 0.93
- Mixed Housekeeping · correlation 0.92
- ER Protein Glycosylation · correlation 0.92
- ATP Synthase Complex · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.