SCUBA

VPS28 — VPS28 subunit of ESCRT-I

VPS28 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

VPS28's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsInterferon-stimulated genes
Anti-viral
APOBEC3G, ARPC4, ARPC5L, BAK1, BST2, DCTN3, ECH1, ETFB +14 moreView in SCUBA
CD8⁺ T cellsStress-ISG Response
Stress
CD53, DDIT4, DRAP1, DYNLRB1, LY6E, PAIP2, PLEKHF1, PSME1 +5 moreView in SCUBA
Gamma-delta T cellsMitochondrial Housekeeping
Mitochondrial & OxPhos
ARL2, BRAT1, C11orf58, CCDC115, CD3E, CHMP4A, CHURC1, DPM3 +13 more
Glial cellsGlutathione Detoxification
Stress
DAD1, GSTP1, ITM2B, MGST3, RABAC1, RHOC, SRP14, TMA7 +1 moreView in SCUBA
Innate lymphoid cellsILC-1 identity
Differentiation
ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3 +20 moreView in SCUBA
Lymphatic endothelialHousekeeping Mixed
Housekeeping
GUK1, LAMTOR4, NDUFB11, NEDD8, PRDX5, RNASEH2C, SSR4, ZNHIT1View in SCUBA
MacrophagesMitochondrial Complex Assembly
Mitochondrial & OxPhos
COX14, LAMTOR1, MRPL43, NDUFA8, NDUFC1, SMIM26, SURF1, TADA3View in SCUBA
Mucosal-associated invariant T cellMitochondrial Housekeeping
Mitochondrial & OxPhos
ARPC3, DUT, GNB2, GPSM3, LSM2, NAA38, NDUFB10, PLEKHJ1 +7 more
Smooth muscle cellsOXPHOS Complex I
Mitochondrial & OxPhos
CLTB, COPS6, ETFB, IAH1, MRPS21, NDUFA2, NDUFB10, NDUFC2 +3 moreView in SCUBA

About the gene

Chromosome8: 144423601-144428563
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Predicted intracellular proteins
Biological processProtein transport, Transport

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.